Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody

Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

PPM1D Antibody is a Rabbit Polyclonal antibody against PPM1D. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

PPM1D

Purified by affinity chromatography.