Inositol Monophosphatase 1 (IMPA1) Antibody

Inositol Monophosphatase 1 (IMPA1)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

IMPA1 Antibody is a Rabbit Polyclonal antibody against IMPA1. This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1, 4, 5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1, 3-diphosphate, myo-inositol-1, 4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

IMPA1

Purified by affinity chromatography.