Polyubiquitin-B (UBB) Antibody

UBB Antibody is a Rabbit Polyclonal antibody against UBB. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasomeThree components are involved in the target protein-ubiquitin conjugation processUbiquitin is first activated by forming a thiolester complex with the ubiquitin-activating enzyme (UBE1 or E1)The activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, and then from E2 to ubiquitin ligase E3 for final delivery to the ε-amino group of the target protein lysine residueCombinatorial interactions of different E2 and E3 proteins result in substRate specificityUBE1 has two isofoms: UBE1a is a nuclear protein of 117 kDa while UBE1b is a nuclear and cytoplasmic protein of 110 kDa.

PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.

UBB

191339

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.