MMP-13 Polyclonal Antibody

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MMP13 encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Collagenase 3 in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11.

Synthesized peptide derived from the N-terminal region of human MMP-13 at AA range: 10-90

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

MMP-13 Polyclonal Antibody detects endogenous levels of MMP-13 protein.