CD59 Polyclonal Antibody

Gel pack with blue ice.

CD59 encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. CD59 glycoprotein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Synthesized peptide derived from the Internal region of human CD59

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

CD59 Polyclonal Antibody detects endogenous levels of CD59 protein.