Cyclin E1 Polyclonal Antibody

Gel pack with blue ice.

The protein encoded by CCNE1 (cyclin E1)belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of CCNE1 has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.

Synthesized peptide derived from human Cyclin E1 around the non-phosphorylation site of T77

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Cyclin E1 Polyclonal Antibody detects endogenous levels of Cyclin E1 protein.