Perforin 1 Polyclonal Antibody

Gel pack with blue ice.

The protein encoded by PRF1 (perforin 1) has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Synthesized peptide derived from Perforin 1 at AA range: 451-500

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Perforin 1 Polyclonal Antibody detects endogenous levels of Perforin 1.