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MAML2 Polyclonal Antibody

MAML2 Polyclonal Antibody

Item no.	ABK-ABP59212-30ul
Manufacturer	Abbkine Scientific
Amount	30 ul
Quantity options	100 ul 200 ul 30 ul
Category	Oncology Neuroscience Molecular Targets for Neuroscience Neural Signaling Antibodies Western Blot ELISA Primary Antibodies By Organ Brain Cancer
Type	Antibody Polyclonal
Applications	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Mastermind-like protein 2,Mam-2
Available
Manufacturer - Applications	Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).
Shipping Temperature	Gel pack with blue ice.
Storage Conditions	Stable for one year at -20C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Background	The protein encoded by MAML2 (Mastermind Like Transcriptional Coactivator 2) is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of MAML2 have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.
Formulation	Liquid solution
Immunogen	Synthesized peptide derived from part region of human MAML2 protein at amino acid sequence of 10-90
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Purification	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
Concentration	1 mg/ml
Other information	The antibody detects endogenous levels of MAML2 protein
Storage Buffer	PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 30 ul

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Delivery expected until 1/1/2026

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