Acetyl P53 (K382) Mouse Monoclonal Antibody (1G7)

Gel pack with blue ice.

TP53(tumor protein p53) encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of TP53 and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons.

Synthetic Peptide of Acetyl P53 (K382)

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

The antibody detects endogenous Acetyl P53(K382) protein.