c-Fgr Polyclonal Antibody

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FGR is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein (FGR proto-oncogene, Src family tyrosine kinase) contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of FGR. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Synthesized peptide derived from the Internal region of human c-Fgr at AA range: 30-110

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

c-Fgr Polyclonal Antibody detects endogenous levels of c-Fgr protein.