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Survivin (phospho Thr34) Polyclonal Antibody

Survivin (phospho Thr34) Polyclonal Antibody

Item no.	ABK-ABP54789-100ul
Manufacturer	Abbkine Scientific
Amount	100ul
Category	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Melanoma Cell Biology Cell Status Western Blot ELISA Autophagy Primary Antibodies Neuronal Cell Markers
Type	Antibody Polyclonal
Applications	ELISA, Western Blot
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Immunogen	Synthesized peptide derived from human Survivin around the phosphorylation site of T34
Applications notes	Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Formulation	Liquid solution
Concentration	1 mg/ml
Storage buffer	PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions	Stable for one year at -20C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping	Gel pack with blue ice.
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Background	Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy. Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division. This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase. Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth.
Gene ID	332
Alternative	BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin
Other info	Phospho-Survivin (T34) Polyclonal Antibody detects endogenous levels of Survivin protein only when phosphorylated at T34.
Accession	O15392

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ul

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Delivery expected until 9/4/2025

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