Ribosomal Protein S6 Polyclonal Antibody

Gel pack with blue ice.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. RPS6 (ribosomal protein S6) encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of RPS6 dispersed through the genome.

Synthesized peptide derived from human Ribosomal Protein S6 around the non-phosphorylation site of S235/S236

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Ribosomal Protein S6 Polyclonal Antibody detects endogenous levels of Ribosomal Protein S6 protein.