Tubulin a1/3/4 (phospho Tyr272) Polyclonal Antibody

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Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. TUBA1A (tubulin alpha 1a) encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Synthesized peptide derived from human Tubulin alpha1/3/4 around the phosphorylation site of Y272

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Phospho-Tubulin alpha1/3/4 (Y272) Polyclonal Antibody detects endogenous levels of Tubulin alpha1/3/4 protein only when phosphorylated at Y272.