SKI-1 Polyclonal Antibody

Gel pack with blue ice.

MBTPS1 (membrane bound transcription factor peptidase, site 1) encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in MBTPS1 may be associated with lysosomal dysfunction.

Synthesized peptide derived from the C-terminal region of human SKI-1 at AA range: 180-260

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

SKI-1 Polyclonal Antibody detects endogenous levels of SKI-1 protein.