Cyclin H (phospho Thr315) Polyclonal Antibody

Gel pack with blue ice.

The protein encoded by CCNH (cyclin H)belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of CCNH is found on chromosome 4. Alternate splicing results in multiple transcript variants.

Synthesized peptide derived from human Cyclin H around the phosphorylation site of T315

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Phospho-Cyclin H (T315) Polyclonal Antibody detects endogenous levels of Cyclin H protein only when phosphorylated at T315.