c-Abl Rabbit Polyclonal Antibody

Gel pack with blue ice.

ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. ABL1 has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9; 22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM: 151410). Alternative splicing of ABL1 results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Recombinant Protein of c-Abl

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

The antibody detects endogenous c-Abl protein.