Cdk5 Polyclonal Antibody

Gel pack with blue ice.

CDK5 encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by CDK5 does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.

Synthesized peptide derived from part region of human Cdk5 protein at amino acid sequence of 1-50

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

The antibody detects endogenous levels of Cdk5