Collagen I Polyclonal Antibody

Gel pack with blue ice.

COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in COL1A2 are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.

Synthesized peptide derived from part region of human Collagen I protein at amino acid sequence of 468-542

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

This antibody detects endogenous levels of Collagen I