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Ataxin-1

Ataxin-1

Manufacturer	Abclonal
Type	Antibody Polyclonal
Specific against	Human
Applications	WB, IF
Protein Family	AKT Signaling
Amount	100ug
Host	Rabbit
Item no.	A0506
eClass 6.1	32160702
eClass 9.0	32160702
Available
*	DESCRIPTION
Calculated MW	87kDa
Immunogen	A synthetic peptide of human ATXN1
Gene ID	6310
Swiss Prot	P54253
Synonyms	Ataxin-1; Spinocerebellar ataxia type 1 protein; ATXN1; ATX1; SCA1
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	Spinocerebellar ataxia 1 (SCA1), an autosomal dominant neurodegenerative disorder, is characterized by slurred speech, loss of limb coordination, and gait abnormalities resulting from the degeneration of cerebellar Purkinje cells and of a subset of brainstem neurons (1). Individuals with SCA1 have a highly polymorphic CAG repeat expansion encoding a polyglutamine tract in ataxin-1 (2). Akt phosphorylates ataxin-1 at Ser776, which regulates an association with 14-3-3. This interaction increases ataxin-1 stabilization and accumulation resulting in enhanced neurodegeneration (3). In addition, HSP70 controls the effect that phosphorylation has on ataxin-1 stability (4).
Recommended Dilutions	WB 1:200-1:500 WB 1:20-1:50
illustration	Western blot analysis of CEM cell lysate using ATXN1 antibody.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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