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GSK690693

GSK690693

Item no.	M1789-200mg
Manufacturer	AbMole
CASRN	937174-76-0
Amount	200mg
Category	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	0,9872
Citations	Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program. Carol H, et al . Pediatr Blood Cancer. 2010 Dec 15,55(7):1329-37. PMID: 20740623 . Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693. Kumar R, et al . BMC Genomics. 2010 Jul 6,11:419. PMID: 20604938 . GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt. Altomare DA, et al . Clin Cancer Res. 2010 Jan 15,16(2):486-96. PMID: 20075391 . AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Levy DS, et al . Blood. 2009 Feb 19,113(8):1723-9. PMID: 19064730 . Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. Heerding DA, et al . J Med Chem. 2008 Sep 25,51(18):5663-79. PMID: 18800763 .
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GSK-690693
Similar products	GSK690693, GSK-690693
Available
Target Information	Akt
Molecular Weight	425, 48
Solubility	DMSO 26 mg/mL
Bioactivity information	GSK690693 is a potent Akt inhibitor (Akt1 IC50 = 2 nM, Akt2 IC50 = 13 nM, Akt3 IC50 = 9 nM) which also inhibited the phosphorylation of the downstream target GSK3b in cells.

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M1789-200mg-safety-datasheet.pdf