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Quarfloxin (CX-3543) 50mg

Quarfloxin (CX-3543) 50mg

Item no.	A12380-50
Manufacturer	Adooq
CASRN	865311-47-3
Amount	50 mg
Quantity options	1 mg 10 mg 100 mg 10mM x 1mL in DMSO 25 mg 5 mg 50 mg
Category	Food Safety Antibiotics Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	>98%
Smiles	CN1CCC[C&commat;H]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CX 3543; Quarfloxacin; CX3543; CX-3543
Similar products	Quarfloxin (CX-3543)
Available
Storage Conditions	2 years at -20C
Molecular Weight	604, 67
Chemical Name	5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3, 2, 1-kl]phenoxazine-2-carboxamide.
Description	Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.
Solubilty	DMSO

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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Delivery expected until 8/14/2025

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