Human Alpha-Synuclein Pre-formed Fibrils Protein, His Tag

C-10xHis, Unconjugated

-70°C

Liquid

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Met 1 - Ala 140

1.0 EU per μg

● The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C;
● The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions;
● The sonicated fibril should be stored at -70°C for not more than 8 weeks.