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Anti-GADD45A

Anti-GADD45A

Item no.	ARP-10-P1402
Manufacturer	American Research Products
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Polyclonal
Specific against	other
Citations	1. Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (Mar 1991). Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Mol Cell Biol 11 (2): 1009-16. 2. Barreto, G., Schafer, A. Marhold, J., Stach, D., Swaminathan, S. K., Handa, V., Doderlein, G., Maltry, N., Wu, W., Lyko, F., Niehrs, C.Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.Nature445: 671-675, 2007.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DNA damage-inducible transcript 1 protein
Available
Description	Rabbit IgG polyclonal antibody for Growth arrest and DNA damage-inducible protein GADD45 alpha ( GADD45A) detection. Tested with WB in Human, Mouse, Rat.
Background	Growth arrest and DNA-damage-inducible protein GADD45 alpha (GADD45A) is a protein that in humans is encoded by the GADD45A gene. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. Papathanasiou et al. (1991) demonstrated that the GADD45 gene is located on 1p34-p12. Sequence analysis of human and hamster cDNA clones demonstrated that the gene has been highly conserved and encodes a novel 165-amino acid polypeptide. Northern blot analysis detected moderate expression of a 1.4-kb GADD45A transcript in heart, skeletal muscle, and kidney, with little or no expression in brain, placenta, lung, liver, and pancreas. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminal of human GADD45A, identical to the related mouse and rat sequence.
Form	Lyophilized
Specificity	Human, Mouse, Rat. No cross reactivity with other proteins.
Storage	2-8C. For long term -20C after reconstitution.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Purification	Immunogen affinity purified.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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