Manufacturer |
American Research Products
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
other |
Amount |
100 ug |
Item no. |
ARP-10-P1619 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Description |
Rabbit IgG polyclonal antibody for Interleukin-5 receptor subunit alpha (IL5RA) detection. Tested with WB in Human. |
Background |
IL5RA INTERLEUKIN 5 RECEPTOR, ALPHA also known as CD125 is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene. The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor which is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The IL5RA gene is mapped to 3p26-p24 by Southern blot analysis of DNA from a panel of mouse-human hybrid somatic cell lines complemented by in situ hybridization. And its Cytogenetic location is 3p26.2. Within this 15-residue stretch of IL5RA, the C-terminal phenylalanine is critical. The binding of this protein to IL5 depends on the beta subunit which is activated by the ligand binding and is required for the biological activities of IL5. |
Immunogen |
A synthetic peptide corresponding to a sequence at the N-terminal of human IL5RA |
Form |
Lyophilized |
Specificity |
Human. No cross reactivity with other proteins. |
Storage |
2-8C. For long term -20C after reconstitution. |
Synonyms |
CDw125, CD_antigen, CD125 |
References |
- 1. Cen, Osman, Gorska Magdalena M, Stafford Susan J, Sur Sanjiv, Alam Rafeul (Mar. 2003). Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.
- 2. Geijsen, N., Uings, I. J., Pals, C., Armstrong, J., McKinnon, M., Raaijmakers, J. A. M., Lammers, J.-W. J., Koenderman, L., Coffer, P. J. Cytokine-specific transcriptional regulation through an IL-5R-alpha interacting protein. Science 293: 1136-1138, 2001.
- 3.Gough, N. M., Rakar, S. Localization of the IL-5 receptor gene to the distal half of murine chromosome 6 using recombinant inbred strains of mice. Genomics 12: 855-856, 1992.
|
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Purification |
Immunogen affinity purified. |
Contents |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.