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NGR Peptide 1 - 1 mg

NGR Peptide 1 - 1 mg

Item no.	AS-60189-1
Manufacturer	AnaSpec
Amount	1 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Format	Lyophilized
Specific against	other
Conjugate/Tag	Unconjugated
Purity	Peak Area by HPLC ≥95%
Sequence	H-Cys-Asn-Gly-Arg-Cys-Gly-Gly-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-NH2 (Disulfide bridge: 1-5)
Citations	1, Ellerby, HM. et al. Nat Med. 5, 1032 (1999) 2, Colombo, G. et al. J. Biol. Chem. 277, 47891 (2002) 3, Van Hensbergen, Y. et al. Biochem. Pharmacol. 63, 897 (2002) 4, Plesniak, L. et al. Protein Sci. 13, 1988 (2004) 5, Zhang Z. et al. Tum Biol. 36(10), 8167-8175 (2015).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CNGRCGGklaklakklaklak-NH2 (Disulfide bridge: 1-5)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Catalog
Manufacturer - Category	Peptides
Manufacturer - Targets	NGR
Shipping Temperature	RT
Storage Conditions	- 20 °C
Molecular Weight	2168.7
Description	This is a peptide with NGR (Asn-Gly-Arg) motif having a disulfide bridge connecting cys1 to cys5 known to elicit antimicrobial property in addition to the presence of KLA sequence. This peptide shows potent cytotoxicity and activity against tumor cells due to its binding to CD13 on tumor cells. This peptide shows dose-dependent antiproliferation against tumor cells and induces cell cylce arrest at G2/M phases and apoptosis of the tumor cells. NGR motif containing peptides are useful in delivering cytotoxic drugs, proapoptotic peptides and tumor necrosis factor (TNF) to tumor vasculature.
Product Group	LB1A3Z
Research Area	Cell Permeable & Penetrating peptides / Lyophilized
Sequence One-Letter Code	CNGRCGGklaklakklaklak-NH2 (Disulfide bridge: 1-5)
GTIN	5400535159351
Usage	Research use
UNSPSC	12352202

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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AS-60189-1-safety-datasheet.pdf