Human recombinant a-Synuclein, HiLyte™ Fluor 488 labeled - 200 µg

Catalog recombinant

Proteins

Dry Ice

The recombinant human a-synuclein (1-140) (GenBank Accession # NP_000336) was expressed and purified from E. coli and conjugated with the fluorescence dye HiLyte Fluor 488. Parkinson's disease is predominantly a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra. The cause of the disease is unknown, but substantial evidence suggests that the aggregation of a-synuclein is a critical step in the etiology of Parkinson's disease (PD). a-Synuclein is an abundant brain protein of 140 residues that is present in high concentrations at presynaptic terminals and is found in both soluble and membrane-associated fractions of the brain. Several possible functions have been suggested, and it appears to be involved in vesicle release and trafficking.

490

5400535009793

10 mM sodium phosphate buffer (pH=7.0)

Research use