Human recombinant a-Synuclein, biotin labeled - 200 µg

ELISA; Aggregation/Fibrillation; Western Blotting

Synuclein

Dry Ice

The recombinant human alpha-synuclein (1-140) (GenBank Accession # NP_000336) was expressed and purified from E. coli and conjugated with biotin. Recombinant protein is produced without an affinity tag. Parkinson's disease is predominantly a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra. The cause of the disease is unknown, but substantial evidence suggests that the aggregation of alpha-synuclein is a critical step in the etiology of Parkinson's disease (PD). alpha-Synuclein is an abundant brain protein of 140 residues that is present in high concentrations at presynaptic terminals and is found in both soluble and membrane-associated fractions of the brain. Several possible functions have been suggested, and it appears to be involved in vesicle release and trafficking. In vitro incubation of alpha-synuclein in the presence of certain amounts of salt (i.e. 0.1M NaCl) with agitation can form fibril structure.

Neuroscience / In solution

1 mg/ml

Recombinant human a-synuclein

12352202