Mouse Monoclonal Antibody to SNAI2

Mouse IgG1

MW: 30kDa
Enterez GeneID: 6591
General Information: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in ¿-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Immunogen: Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide. ;
Reconstitution and Storage: Reconstituted with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000
References: 1. Nat Methods. 2005 Aug; 2(8):591-8. ; 2. J Cell Physiol. 2006 Dec; 209(3):695-700. Review. ; 3. J Biol Chem. 2006 Dec 1; 281(48):36977-84. Epub 2006 Oct 5.