Mouse Monoclonal Antibody to MCAM

Mouse IgG1

MW: 71.6kDa
Enterez GeneID: 4162
General Information: The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. ; ;
Immunogen: Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. Coli.
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage: Reconstituted with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: 1 to 200 - 1 to 1000; FCM: 1 to 200 - 1 to 400
References: 1. Dev Biol. 2012 Feb 1; 362(1):94-103. ; 2. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):18969-74. ;