Mouse Monoclonal Antibody to MET

Catalog Number: sAP-1429
Product Name: Mouse Monoclonal Antibody to MET
Target Molecle: MET
Aliases: E2-2; ITF2; PTHS; SEF2; FECD3; ITF-2; SEF-2; TCF-4
Species: Human; Monkey;
MW: 71.3kDa
Enterez GeneID: 6925
General Information: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.;
Immunogen: Purified recombinant fragment of human MET (AA: 743-932) expressed in E. Coli.
Clone: MM5E9C4;
Isotype: Mouse IgG1
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: 1 to 200 - 1 to 1000; ICC: 1 to 200 - 1 to 1000; FCM: 1 to 200 - 1 to 400
References: 1.PLoS Biol. 2014 Dec 23; 12(12):e1002026. ; 2.Oncotarget. 2014 Apr 15; 5(7):1793-804.;