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Anti-5-HT2C Receptor/HTR2C Antibody Picoband®

Anti-5-HT2C Receptor/HTR2C Antibody Picoband®

Item no.	BOS-A01593-1-carrier-free
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Metabolism Regulation of Appetite Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody
Format	Lyophilized
Applications	WB, ELISA
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Brennan, T. J., Seeley, W. W., Kilgard, M., Schreiner, C. E., Tecott, L. H. Sound-induced seizures in serotonin 5-HT-2C receptor mutant mice. Nature Genet. 16: 387-390, 1997. 2. Di Narzo, A. F., Kozlenkov, A., Roussos, P., Hao, K., Hurd, Y., Lewis, D. A., Sibille, E., Siever, L. J., Koonin, E., Dracheva, S. A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide. Hum. Molec. Genet. 23: 4801-4813, 2014. 3. Doe, C. M., Relkovic, D., Garfield, A. S., Dalley, J. W., Theobald, D. E. H., Humby, T., Wilkinson, L. S., Isles, A. R. Loss of imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT(2C)R-mediated behaviour. Hum. Molec. Genet. 18: 2140-2148, 2009.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Neutrophil cytosol factor 1,NCF-1,47 kDa autosomal chronic granulomatous disease protein,47 kDa neutrophil oxidase factor,NCF-47K,Neutrophil NADPH oxidase factor 1,Nox organizer 2,Nox-organizing protein 2,SH3 and PX domain-containing protein 1A,p47-phox,NCF1,NOXO2,SH3PXD1A
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Conjugate / Tag	carrier-free
Storage Conditions	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Observed Molecular weight	75 kDa
Calculated Molecular weight	34140 MW
Clonality	Polyclonal
Application Details	Western blot, 0.25-0.5 μg/ml, Rat ELISA, 0.1-0.5 μg/ml
Gene Name	HTR2C
Gene Full Name	neutrophil cytosolic factor 1
Background	This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.
Immunogen	E.coli-derived human 5-HT2C Receptor/HTR2C recombinant protein (Position: N372-V458).
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cancer, Cancer Metabolism, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction
Protein Name	Growth/differentiation factor 15
Protein Function	NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Subcellular Localization	Cytoplasm, cytosol.
Description	Boster Bio Anti-5-HT2C Receptor/HTR2C Antibody Picoband® catalog # A01593-1. Tested in ELISA, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Detected in peripheral blood monocytes and neutrophils (at protein level).
Manufacturer - Alias	Neutrophil cytosol factor 1, NCF-1, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-47K, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox-organizing protein 2, SH3 and PX domain-containing protein 1A, p47-phox, NCF1, NOXO2, SH3PXD1A
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-A01593-1-carrier-free-datasheet.pdf

BOS-A01593-1-carrier-free-safety-datasheet.pdf