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Anti-FNDC5 Antibody Picoband®

Anti-FNDC5 Antibody Picoband®

Item no.	BOS-A02538-1-Dylight594
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Obesity Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Primary
Format	Lyophilized
Applications	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	DyLight 594
Citations	1. Erickson HP (October 2013). Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?. Adipocyte. 2 (4): 289–93. 2. Staiger, H., Bohm, A., Scheler, M., Berti, L., Machann, J., Schick, F., Machicao, F., Fritsche, A., Stefan, N., Weigert, C., Krook, A., Haring, H.-U., de Angelis, M. H. Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity. PLoS One 8: e61903, 2013.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Fibronectin type III domain-containing protein 5,Fibronectin type III repeat-containing protein 2,Irisin,FNDC5,FRCP2
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	23 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml ELISA, 0.1-0.5μg/ml
Gene Name	FNDC5
Gene Full Name	fibronectin type III domain containing 5
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene. This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants.
Immunogen	E. coli-derived human FNDC5 recombinant protein (Position: D32-E143).
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cell Biology, Metabolism, Obesity
Protein Function	Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
Subcellular Localization	Cell membrane.
Description	Boster Bio Anti-FNDC5 Antibody Picoband® catalog # A02538-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-A02538-1-Dylight594-datasheet.pdf

BOS-A02538-1-Dylight594-safety-datasheet.pdf