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Anti-CRLF2 Antibody Picoband®

Anti-CRLF2 Antibody Picoband®

Item no.	BOS-A04167-1-FITC
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Antibodies By Cell Type Hematology Leukemia Lymphoma Western Blot ELISA Primary Antibodies By Organ Heart & Blood Cancer Immunostaining
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	FITC
Citations	1. Entrez Gene: CRLF2 cytokine receptor-like factor 2. 2. Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T (Jul 2001). Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR. Cytogenet Cell Genet. 93 (1–2): 23–5. 3. Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X (Mar 2001). Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. Biochem Biophys Res Commun. 281 (4): 878–83.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Cytokine receptor-like factor 2,Cytokine receptor-like 2,IL-XR,Thymic stromal lymphopoietin protein receptor,TSLP receptor,CRLF2,CRL2,ILXR,TSLPR
Available
Manufacturer - Applications	ELISA (Cap), WB
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	65-75 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml ELISA (Cap), 1-5μg/ml
Gene Name	CRLF2
Gene Full Name	cytokine receptor like factor 2
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Cytokine receptor-like factor 2 is a protein that in humans is encoded by the CRLF2 gene. This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
Immunogen	E. coli-derived human CRLF2 recombinant protein (Position: A26-K231).
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cytokines, Immunology, Innate Immunity
Protein Function	Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.
Subcellular Localization	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Description	Boster Bio Anti-CRLF2 Antibody Picoband® catalog # A04167-1. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A04167-1-FITC-datasheet.pdf

BOS-A04167-1-FITC-safety-datasheet.pdf