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Anti-SORBS1 Picoband® Antibody

Anti-SORBS1 Picoband® Antibody

Item no.	BOS-A04426-3-Dylight488
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Antibodies By Cell Type Carcinoma Flow Cytometry Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Primary Antibody
Format	Lyophilized
Applications	WB, FC, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	DyLight 488
Sensitivity	>5000 cells
Citations	1. Lin, W.-H., Chiu, K. C., Chang, H.-M., Lee, K.-C., Tai, T.-Y., Chuang, L.-M. Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes. Hum. Molec. Genet. 10: 1753-1760, 2001. 2. Mastick, C. C., Brady, M. J., Saltiel, A. R. Insulin stimulates the tyrosine phosphorylation of caveolin. J. Cell Biol. 129: 1523-1531, 1995. 3. Ribon, V., Printen, J. A., Hoffman, N. G., Kay, B. K., Saltiel, A. R. A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Molec. Cell. Biol. 18: 872-879, 1998.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Sorbin and SH3 domain-containing protein 1,Ponsin,SH3 domain protein 5,SH3P12,c-Cbl-associated protein,CAP,SORBS1,KIAA0894,KIAA1296,SH3D5
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	160 kDa
Calculated Molecular weight	143 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.25-0.5μg/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human ELISA, 0.1-0.5μg/ml
Gene Name	SORBS1
Gene Full Name	sorbin and SH3 domain containing 1
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	CAP/Ponsinprotein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SORBS1 gene. It is mapped to 10q24.1. This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants.
Immunogen	E.coli-derived human SORBS1 recombinant protein (Position: Q23-R323).
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cancer, Cardiovascular, Cell Type Markers, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Tags & Cell Markers, TNF Superfamily, Vasculature
Protein Function	Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Subcellular Localization	Cell membrane. Nucleus. Nucleus matrix. Cytoskeleton. Adherens junction. Focal adhesion.
Description	Boster Bio Anti-SORBS1 Picoband® Antibody catalog # A04426-3. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A04426-3-Dylight488-datasheet.pdf

BOS-A04426-3-Dylight488-safety-datasheet.pdf