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Anti-Mad/MXD1 Antibody Picoband®

Anti-Mad/MXD1 Antibody Picoband®

Item no.	BOS-A06485-1-carrier-free
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Antibodies Western Blot ELISA Primary Antibodies By Organ Heart & Blood Cancer Immunostaining
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Edelhoff, S., Ayer, D. E., Zervos, A. S., Steingrimsson, E., Jenkins, N. A., Copeland, N. G., Eisenman, R. N., Brent, R., Disteche, C. M. Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to chromosome 10 and mouse chromosome 19. Oncogene 9: 665-668, 1994. 2. Shapiro, D. N., Valentine, V., Eagle, L., Yin, X., Morris, S. W., Prochownik, E. V. Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25. Genomics 23: 282-285, 1994.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Max dimerization protein 1,Max dimerizer 1,Protein MAD,MXD1,MAD
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Conjugate / Tag	carrier-free
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	28 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml ELISA, 0.1-0.5μg/ml
Gene Name	MXD1
Gene Full Name	MAX dimerization protein 1
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	MAD protein is a protein that in humans is encoded by the MXD1 gene. This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Immunogen	E. coli-derived human Mad recombinant protein (Position: M1-L221).
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Transcription
Protein Function	Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.
Subcellular Localization	Nucleus.
Description	Boster Bio Anti-Mad/MXD1 Antibody Picoband® catalog # A06485-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-A06485-1-carrier-free-datasheet.pdf

BOS-A06485-1-carrier-free-safety-datasheet.pdf