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Anti-POGLUT1 Antibody Picoband®

Anti-POGLUT1 Antibody Picoband®

Item no.	BOS-A06826-1-PE
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Metabolism Glucose Homeostasis Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies Immunochemistry
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IF, IHC, ICC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	PE
Citations	1. Basmanav, F. B., Oprisoreanu, A.-M., Pasternack, S. M., Thiele, H., Fritz, G., Wenzel, J., Grosser, L., Wehner, M., Wolf, S., Fagerberg, C., Bygum, A., Altmuller, J., and 9 others. Mutations in POGLUT1, encoding protein O-glucosyltransferase 1, cause autosomal-dominant Dowling-Degos disease. Am. J. Hum. Genet. 94: 135-143, 2014. 2. Chu, Q., Liu, L., Wang, W. Overexpression of hCLP46 enhances Notch activation and regulates cell proliferation in a cell type-dependent manner. Cell Prolif. 46: 254-262, 2013. 3. Hanneken, S., Rutten, A., Eigelshoven, S., Braun-Falco, M., Pasternack, S. M., Ruzicka, T., Nothen, M. M., Betz, R. C., Kruse, R. Morbus Galli-Galli: klinische und histopathologische Untersuchung anhand einer Fallserie von 18 Patienten. Hautarzt 62: 842-851, 2011.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Intraflagellar transport protein 88 homolog,Recessive polycystic kidney disease protein Tg737 homolog,Tetratricopeptide repeat protein 10,TPR repeat protein 10,IFT88,TG737,TTC10
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	55 kDa
Calculated Molecular weight	104553 MW
Clonality	Polyclonal
Application Details	Western blot, 0.25-0.5μg/ml, Human, Mouse Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human Immunocytochemistry/Immunofluorescence, 5μg/ml, Human
Gene Name	POGLUT1
Gene Full Name	intraflagellar transport 88
Background	This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants.
Immunogen	A synthetic peptide corresponding to a sequence at C-terminus of human POGLUT1, which shares 92.6% and 88.9% amino acid (aa) sequence identity with mouse and rat POGLUT1, respectively.
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cell Adhesion Proteins, ECM Proteins, Neuroscience
Protein Name	AP-2 complex subunit beta
Protein Function	Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
Subcellular Localization	Centriole. Cilium basal body. Centrosome. Cilium. Cytoplasm. Flagellum.
Description	Boster Bio Anti-POGLUT1 Antibody Picoband® catalog # A06826-1. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-A06826-1-PE-datasheet.pdf

BOS-A06826-1-PE-safety-datasheet.pdf