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Anti-p23/PTGES3 Antibody Picoband® (monoclonal, 9D3D1)

Anti-p23/PTGES3 Antibody Picoband® (monoclonal, 9D3D1)

Item no.	BOS-M04136-3-FITC
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Metabolism Cholesterol & Lipid Metabolism Antibodies Flow Cytometry Western Blot Immunofluorescence Immunocytochemistry Enzymes Prostaglandin Synthases Primary Antibodies Immunochemistry
Type	Antibody Monoclonal
Format	Lyophilized
Applications	WB, FC, IF, ICC
Clone	9D3D1
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG2b
Conjugate/Tag	FITC
Sensitivity	<5 pg/ml
Citations	1. Weaver AJ, Sullivan WP, Felts SJ, et al. (2000). Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. J. Biol. Chem. 275 (30): 23045–23052. 2. Tanioka T, Nakatani Y, Semmyo N, et al. (2000). Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J. Biol. Chem. 275 (42): 32775–32782. 3. Dittmar KD, Pratt WB (1997). Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. J. Biol. Chem. 272 (20): 13047–13054.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	SUMO-activating enzyme subunit 2,Anthracycline-associated resistance ARX,Ubiquitin-like 1-activating enzyme E1B,Ubiquitin-like modifier-activating enzyme 2,UBA2,SAE2,UBLE1B,HRIHFB2115
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Observed Molecular weight	23 kDa
Clonality	Monoclonal
Application Details	Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
Gene Name	PTGES3
Gene Full Name	ubiquitin like modifier activating enzyme 2
Background	Prostaglandin E synthase 3 (cytosolic)is anenzymethat in humans is encoded by the PTGES3gene. It is mapped to 12q13.3; 12. This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes.
Immunogen	E.coli-derived human p23/PTGES3 recombinant protein (Position: M1-K79).
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cell Adhesion Proteins, Epigenetics and Nuclear Signaling, Integrins, Mediator Complex, Neuroscience, Receptors, Transcription
Protein Function	The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Subcellular Localization	Nucleus; Cytoplasm
Description	Boster Bio Anti-p23/PTGES3 Antibody Picoband® (monoclonal, 9D3D1) catalog # M04136-3. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M04136-3-FITC-datasheet.pdf

BOS-M04136-3-FITC-safety-datasheet.pdf