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Anti-C-C chemokine receptor type 4 CCR4 Antibody Picoband®

Anti-C-C chemokine receptor type 4 CCR4 Antibody Picoband®

Item no.	BOS-PA1517-HRP
Manufacturer	Boster
Amount	100 ug
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Western Blot Cardiovascular Research Atherosclerosis Primary Antibodies
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	HRP
Sensitivity	<15 pg/ml
Sequence	Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Citations	1. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S., Yoshie, O.The T cell-ed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.J. Biol. Chem. 272: 15036-15042, 1997. 2. Imai, T., Chantry, D., Raport, C. J., Woods, C. L., Nishimura, M., Godiska, R., Yoshie, O., Gray, P. W.Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.J. Biol. Chem. 273: 1764-1768, 1998. 3. Oo, Y. H., Weston, C. J., Lalor, P. F., Curbishley, S. M., Withers, D. R., Reynolds, G. M., Shetty, S., Harki, J., Shaw, J. C., Eksteen, B., Hubscher, S. G., Walker, L. S. K., Adams, D. H.Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.J. Immun. 184: 2886-2898, 2010.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	C-C chemokine receptor type 4,C-C CKR-4,CC-CKR-4,CCR-4,CCR4,CD194,Ccr4,Cmkbr4
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	41 kDa
Calculated Molecular weight	41408 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml, Mouse, Rat
Gene Name	CCR4
Gene Full Name	C-C chemokine receptor type 4
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	CCR4, C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194). The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines. The CCR4 gene is mapped to chromosome 3. Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of mouse CCR4, identical to the related rat sequence.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Atherosclerosis, Cardiovascular, Chemokines, Immunology, Innate Immunity, Vascular Inflammation
Protein Name	C-C chemokine receptor type 4(C-C CKR-4/CC-CKR-4/CCR-4/CCR4)
Protein Function	High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G (i) proteins which activate a phosphatidylinositol- calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.
Subcellular Localization	Cell membrane; Multi-pass membrane protein.
Description	Boster Bio Anti-C-C chemokine receptor type 4 CCR4 Antibody catalog # PA1517. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed in the thymus, macrophages and T- and B-cells.
Sequence Similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-PA1517-HRP-datasheet.pdf

BOS-PA1517-HRP-safety-datasheet.pdf