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Anti-Bag5 Antibody Picoband®

Anti-Bag5 Antibody Picoband®

Item no.	BOS-PA2101-carrier-free
Manufacturer	Boster
Amount	100 ug/vial
Quantity options	100 ug/vial 10 ug 100 ug/vial 100 ug/vial 100 ug/vial 100 ug 100 ug 100 ug 100 ug/vial 100 ug/vial 100 ug/vial 100 ug/vial 100 ug
Category	Oncology Neuroscience Neuroinflammation Neural Mitochondrial Function Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Status Apoptosis Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Autophagy Primary Antibodies By Organ Colorectal Cancer Testicular & Prostate Cancer Immunochemistry
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, FC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<10 pg/ml
Sequence	Contains 5 BAG domains.
Citations	1. Takayama S, Xie Z, Reed JC (Feb 1999). An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem 274 (2): 781–6. 2 Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (Dec 2004). BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 44 (6): 931–45. 3 Entrez Gene: BAG5 BCL2-associated athanogene 5.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	BAG family molecular chaperone regulator 5,BAG-5,Bcl-2-associated athanogene 5,BAG5,KIAA0873
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Conjugate / Tag	carrier-free
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	51 kDa
Calculated Molecular weight	51200 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
Gene Name	BAG5
Gene Full Name	BAG family molecular chaperone regulator 5
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene. The protein encoded by this gene is a member of the BAG1-related protein family. Bag5 is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death and thus promotes neurodegeneration.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human BAG5, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Apoptosis, Apoptotic Markers, Cancer, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes
Protein Name	BAG family molecular chaperone regulator 5
Protein Function	Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
Subcellular Localization	Cytoplasm.
Description	Boster Bio Anti-Bag5 Antibody catalog # PA2101. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Sequence Similarities	Contains 5 BAG domains.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-PA2101-carrier-free-datasheet.pdf

BOS-PA2101-carrier-free-safety-datasheet.pdf