Comparison

LATS1(Phospho-Thr1079) Rabbit Polyclonal Antibody

Item no. BT-AP11010-50ul
Manufacturer Bioassay Technology Laboratory
Amount 50 ul
Category
Type Antibody Polyclonal
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host Rabbit
Isotype IgG
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias LATS1 ;Thr1079 ; Serine/threonine-protein kinase LATS1; EC 2.7.11.1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts
Available
Background
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner| with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity| indicating a role as a negative regulator of CDC2/cyclin A. In addition| the C-terminal kinase domain binds to its own N-terminal region| suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas| ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen
Clonality
Polyclonal
Concentration
1 mg/ml
Immunogen
Synthesized phosho peptide around human LATS1 (Thr1079)
Storage Stability
-20°C for 1 year

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 ul
Available: In stock
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