Comparison

MED28 Polyclonal Antibody

Item no. BT-AP11216
Manufacturer Bioassay Technology Laboratory
Amount 20 ul
Category
Type Antibody Polyclonal
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Mediator of RNA polymerase II transcription subunit 28 ;Endothelial-derived protein 1;Mediator complex subunit 28;Merlin and Grb2-interacting cytoskeletal protein;Magicin;Tumor angiogenesis ma
Available
Background
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways., induction:Up-regulated by endothelial cells when exposed to tumor conditional media., Belongs to the Mediator complex subunit 28 family., subcellular location:According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated., subunit:Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Forms a ternary complex with NF2/merlin and GRB2. Binds to actin., tissue specificity:Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.,
Clonality
Polyclonal
Concentration
1 mg/ml
Immunogen
Synthesized peptide derived from human protein . at AA range: 20-100
Storage Stability
-20°C for 1 year

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 20 ul
Available: In stock
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