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Purified Anti-Mouse CD54 Antibody[YN1/1.7.4]

Purified Anti-Mouse CD54 Antibody[YN1/1.7.4]

Item no.	E-AB-F1018A-1mg
Manufacturer	Elabscience
Amount	1 mg
Quantity options	100 ug 100 mg 1 mg 25 ug 25 mg 50 ug 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Hematology Myeloma Cell Biology Cell Movement Cell Adhesion Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	FC
Clone	YN1/1.7.4
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Intercellular adhesion molecule 1, Icam1, MALA-2, MyD10, CD54, Icam-1,
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Applications	FCM
Manufacturer - Category	Flow Cytometry Antibodies
Manufacturer - Isotype	Rat IgG2b, κ
Manufacturer - Targets	CD54
Shipping Temperature	Ice bag
Storage Conditions	Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Background	CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.
Concentration	≥1 mg/mL
Buffer	Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
Abbreviation	CD54
Clonality	Monoclonal
Usage	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.