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Evolocumab

Evolocumab

Item no.	HY-P9930-25mg
Manufacturer	MedChem Express
CASRN	1256937-27-5
Amount	25 mg
Quantity options	10 mg 1 mg 25 mg 50 mg 5 mg
Category	Antibodies Primary Antibodies
Type	Antibody
Specific against	other
Purity	98.40
Citations	[1]Fala L, et, al. Repatha (Evolocumab): Second PCSK9 Inhibitor Approved by the FDA for Patients with Familial Hypercholesterolemia. Am Health Drug Benefits. 2016 Mar;9(Spec Feature):136-9.\|[2]Zhou Q, et al. Protective effect of evolocumab on Müller cells in the rat retina under hyperglycaemic and hypoxic conditions. J Diabetes Complications. 2023 Oct;37(10):108593.\|[3]Safaeian L, et al. Evolocumab, a PCSK9 inhibitor, protects human endothelial cells against H2O2-induced oxidative stress. Arch Physiol Biochem. 2022 Dec;128(6):1681-1686.
Smiles	[Evolocumab]
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AMG 145
Shipping Condition	Cool pack
Available
Manufacturer - Type	Inhibitory Antibodies
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	NF-κB; Ser/Thr Protease; Toll-like Receptor (TLR)
Shipping Temperature	Blue Ice
Storage Conditions	Store at 4°C for 2 years, do not freeze
Molecular Weight	(141.8 kDa)
Product Description	Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H2O2-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation[1][2][3].
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Solubility	H2O
Manufacturer - Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Clinical information	Launched

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HY-P9930-25mg-safety-datasheet.pdf