Comparison

Anti-PSD-95 MAGUK Scaffold Protein Antibody

Item no. 75-348
Manufacturer Antibodies Incorporated
Amount 100 uL
Category
Type Antibody Monoclonal
Format Liquid
Applications WB, IHC, ICC
Clone K28/74
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Primate
Host Mouse
Isotype IgG1
Conjugate/Tag Unconjugated
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Shipping Condition Cool pack
Available
Manufacturer - Type
Primary Antibody
Manufacturer - Applications
AT, ICC, IHC, WB
Manufacturer - Targets
PSD-95 MAGUK scaffold protein
Country of Origin
United States
Shipping Temperature
Shipped on ice packs
Storage Conditions
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Molecular Weight
95-110 kDa (varies with cell background due to phosphorylation)
Manufacturer - Research Area
Cell Markers, Neuronal Markers, Synapse Markers, Post-synaptic Markers, Scaffold Proteins
Expiration
24 months from date of receipt
Immunogen
Fusion protein amino acids 77-299 (PDZ domains 1 and 2) of human PSD-95 (accession number P78352) produced recombinantly in E. Coli
Immunogen Species
Human
Description
Our Anti-PSD-95 MAGUK scaffold protein mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K28/74. It is KO validated, detects human, mouse, and rat PSD-95 MAGUK scaffold protein, and is purified by Protein A chromatography. It is great for use in AT, IHC, ICC, WB.
Target Description
PSD-95 is a member of the MAGUK (membrane associated guanylate kinase) family (which also includes PSD-93, SAP97 and SAP102) and functions as a scaffold protein that can cluster membrane receptors, ion channels, including NMDA receptor subunits, Kv1 potassium channels and Caspr2. The protein is encoded by DLG4, contains hallmark PDZ, SH3 and GuK domains and is found at post synaptic densities where it plays an important role in the formation and maintenance of synaptic junctions (Zhou and Blumberg, 2003). Indeed, overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. Antibodies against PSD95/DLG4 are frequently used in conjunction with pre-synaptic markers to localize synapses by microscopy
Clonality
Monoclonal
Manufacturer - Specificity
Does not cross-react with DLG1/SAP97
Concentration
1 mg/mL
Form
Purified by Protein A chromatography
Buffer
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Production Notes
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Quality Control
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Quality Control: Application
WB Brain
Dilution Range: WB
1:1000
Dilution Range: IHC
1:1000
Dilution Range: ICC
1:1000
Usage Statement
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Manufacturer - Statement
We produce our PSD-95 MAGUK scaffold protein mouse monoclonal primary antibody from hybridoma clone K28/74. It is great in AT, IHC, ICC, WB and is purified by Protein A chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 uL
Available: In stock
available

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