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Klotho Antibody (C-term) [APR07121G]

Klotho Antibody (C-term) [APR07121G]

Item no.	LBI-APR07121G
Manufacturer	Leading Biology
Amount	100 ul
Quantity options	100 ul
Category	Metabolism Diabetes Antibodies Flow Cytometry Western Blot ELISA Primary Antibodies
Type	Antibody
Format	Liquid
Applications	WB, FC
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Klotho, Klotho peptide, KL
Available
Manufacturer - Type	Polyclonal Antibodies
Manufacturer - Category	Abs-G
Storage Conditions	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight	116181
Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Klotho Antibody (C-term) [APR07121G].
Manufacturer - Specificity	This Klotho antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 986-1012 amino acids from the C-terminal region of human Klotho.
Cellular localization	[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Apical cell membrane {ECO:0000250\|UniProtKB:O35082}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:O35082}. Note=Isoform 1 shedding leads to a soluble peptide. {ECO:0000250\|UniProtKB:O35082} [Klotho peptide]: Secreted {ECO:0000250\|UniProtKB:O35082}
Gene Name	KL
Function	May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
Summary	Tissue Location: Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid Expressed in kidney, placenta, small intestine and prostate. Down- regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.
Manufacturer - Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	WB-1:1000
Clonality	Polyclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 10/16/2025

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