Anti-Mouse CD90 (Thy-1) (Clone M5/49.4.1) - Purified <i>in vivo </i>PLATINUM™ Functional Grade - 50 mg

Depletion, FA, IP

2 - 8°C Wet Ice

Thy1 is a highly conserved, GPI-linked member of the immunoglobulin superfamily that isimportant in the immune and nervous systems1 and involved in T-cell activation and cell-cellinteractions2. The effects of Thy1 are context-dependent1. Thy1 is heavily N-glycosylated with acarbohydrate content of up to 40% of its molecular mass, and its moiety composition variesbetween tissues as well as between cells of the same lineage in different stages of differentiation.Additionally, Thy1 is found in both membrane-bound and soluble forms, and, in mice, Thy1 isencoded by two alleles, Thy1.1 and Thy1.2, which are distinguished by a single amino acid atposition 891. Thy1 deficiency does not compromise immunity2, but its presence or absencemodulates the phenotypes of certain cancers, fibrotic diseases, and neuronal injury1. Thy1.1 is analloantigen of the AKR/J and PL mouse strains, whereas Thy1.2 is expressed by most mousestrains2, 3. M5/49.4.1 was generated by immunizing (Lewis x BN) F1 rats with a secondary mixedlymphocyte culture consisting of C57BL/6 mouse anti-irradiated BN rat lymphoma4. Spleencells were fused with NS-1 myeloma cells and hybridomas grown and assessed for binding tocytolytic T lymphocyte (CTL) surface molecules.

≥ 5.0 mg/ml

CD90 is expressed in mice by thymocytes, peripheral T-cells, myoblasts, epidermal cells, and keratinocytes. CD90 is considered a pan T cell marker of mice.