Anti-Human EGFR (Clone 225) - Recombinant <i>in vivo</i> Functional Grade - 1.0 mg

2 - 8°C Wet Ice

Epidermal growth factor receptor (EGFR, also known as ErbB1 or HER 1) is a glycoprotein that belongs tothe receptor tyrosine kinase. It plays a role in activating signaling pathways essential, for cellularproliferation, differentiation, and survival1-3. During embryogenesis organogenesis and throughoutadulthood EGFR is involved in processes such as tissue growth, differentiation, maintenance, and repair2. Moreover, EGFR acts as a host factor for viral entry in diseases like hepatitis B4, hepatitis C5, andgastroenteritis6. It has also been found to play a role in SARS-CoV-2 infection7-9.Dysregulation of EGFR due to mutation or altered signaling is associated with diseases like Parkinson’s2, Alzheimer’s1, 2, and amyotrophic lateral sclerosis2. Additionally, it has been implicated in thedevelopment of cancers including lung, glioblastoma, brain, breast, colorectal, and ovarian3. The bindingof ligands to EGFR in cancer cells has been linked to abnormal cell proliferation, invasion, metastasis, angiogenesis, and reduced apoptosis10. Consequently, EGFR serves as a target for cancer treatmentsincluding monoclonal humanized antibodies such as panitumumab and cetuximab along with selectivesmall molecule inhibitors11-13.Human Anti-EGFR antibody, clone 225 is a research-grade biosimilar of the monoclonal antibody drugcetuximab. This chimeric antibody contains components from both humans and mice. 225 has beenextensively researched in forms of cancer such, as head and neck cell carcinoma, colorectal cancer, andnon-small cell lung cancer. Studies have shown that it can be effective when used alongsidechemotherapy or radiation therapy presenting an opportunity to enhance outcomes14-22.

≥ 5.0 mg/ml

EGFR is overexpressed on the cell surfaces of various tumor cell types and is alsofound in the plasma membranes, cytoplasm, and cell junctions of many healthy tissues, including thoseassociated with the Skin – Epidermis development cluster of The Human Protein Atlas. EGFR is alsofound in the blood secretome.