Anti-NDRG2 Antibody

Primary Antibody

NDRG2

Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody.

200 µg/mL

WB, WB Brain, IHC, ICC

Our Anti-NDRG2 chicken polyclonal primary antibody from Aves Labs is produced in-house. It detects human, mouse, and rat NDRG2, and is affinity-purified IgY. It is great for use in IHC, ICC, WB.

NDRG2, or N-myc downstream-regulated gene 2, is a downstream target of the N-myc proto-oncogene. NDRG2 was initially identified for its role in cell differentiation and response to cellular stress. Multiple studies have determined that NDRG2 mRNA is downregulated or undetectable in several human cancers, and over-expression of NDRG2 inhibited the proliferation of cancer cells. Commonly regarded as a tumor suppressor, NDRG2 also plays a crucial role in regulating cell proliferation, apoptosis, and metastasis. In neuroscience, studies of astrocytes in the central nervous system have implicated NDRG2 in the pathogenesis of many neurological diseases not limited to tumors; including stroke, neurodegenerative diseases, and psychiatric disorders. Its involvement in maintaining the integrity of the blood-brain barrier adds to its significance in neurobiology (Takarada-Iemata et al. Glia, 2018). Drug therapies to modulate the expression of NDGR2 may be able to help patients suffering from disease states ranging from multiple cancer types to Alzheimer’s, Parkinson’s, and depression.

Polyclonal

1:100-1:500

Recombinant protein encompassing the N-terminal ~150 amino acids of human NDRG2

No cross-reactivity reported

12 months from receipt of product

Eggs from hens hyperimmunized with target were used to prepare an IgY fraction which was then subjected to antigen-specific affinity purification