Anti-ERAB Polyclonal Antibody

Polyclonal Antibody

Rabbit IgG

27

HSD17B10

Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer

Mutations in several genes associated with early onset Alzheimer's result in increased extracellular concentRations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen, a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer's disease-affected brain.
ERAB may contribute to neuronal dysfunction in Alzheimer's disease.

Affinity Purified

HSD17B10