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SST Antibody - C-terminal region

SST Antibody - C-terminal region

Item no.	OABB01208
Manufacturer	AVIVA Systems Biology
Amount	100 ug/vial
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies Immunohistochemistry Western Blot ELISA Immunocytochemistry Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	all-trans-retinyl-palmitate hydrolase;BCO family,member 3;BCO3;LCA2;lutein isomerase;meso-zeaxanthin isomerase;mRPE65;p63;RBP-binding membrane protein;rd12;retinal pigment epithelium specific protein 65;retinal pigment epithelium-specific 65 kDa protein;retinal pigment epithelium-specific protein 65kDa;retinitis pigmentosa 20 (autosomal recessive);retinoid isomerohydrolase;retinol isomerase;RP20;RPE65,retinoid isomerohydrolase;sRPE65.
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	RPE65
Gene Fullname	retinoid isomerohydrolase RPE65
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	SST(Somatostatin), also known as SMST, is a peptide hormone. Naylor et al.(1983) assigned the somatostatin gene to chromosome 3 by analyzing somatic cell hybrids with a polymorphic gene probe. Yacubova and Komuro(2002) examined the effects of somatostatin in cerebellar granule cells of early postnatal mice, because these cells express all 5 types of somatostatin receptors before the initiation of their migration. Saito et al.(2005) found that somatostatin modulated the proteolytic degradation of beta-amyloid catalyzed by neprilysin both in vitro and in vivo.
Protein name	Retinoid isomerohydrolase
Clonality	Recombinant Monoclonal
Purification	Affinity Purified
Immunogen	A synthesized peptide derived from human RPE65
Dilution	Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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OABB01208-datasheet.pdf

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Amount: 100 ug/vial

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Delivery expected until 12/25/2025

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